Endocrine Abstracts

A 25-year old woman with Hashimoto thyroiditis was referred to the endocrinology department for investigation of a 40 kilogram weight gain, polyuria, polydipsia and secondary amenorrhea. Hormonal work-up showed diabetes insipidus, central hypogonadism, secondary adrenal insufficiency, central hypothyroidism and slight hyperprolactinemia. Pituitary magnetic resonance imaging (MRI) revealed a 15 mm hypothalamic tumor expanding to the infundibulum, associated with pituitary stalk...

Background: Patients with type 2 diabetes and overweight have a chronic activation of the innate immune system possibly explaining the increased risk of a hyperinflammatory response and severe COVID-19. We aimed to test whether blockade of interleukin-1β(IL-1β) using canakinumab improves clinical outcome.Methods: CanCovDia was a multicenter, randomised, double-blind, placebo-controlled trial to assess the efficacy of canakinumab plus standard-o...